Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2.

@article{Yu1997RegulationOM,
  title={Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2.},
  author={Kang Kang Yu and Christina P Ravera and Y. N. Chen and Gerald McMahon},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1997},
  volume={8 7},
  pages={731-42}
}
Deregulated overexpression of c-Myc (Myc) confers susceptibility to apoptosis in several cell types, but the molecular regulation of these processes has not been well established. Here we have characterized several molecular changes that may modulate Myc-dependent apoptosis. Ectopic overexpression of Myc in both Rat1 fibroblasts and human osteosarcoma cells causes a dramatic increase of cellular p53 mRNA and protein, and this induction of p53 correlates with apoptosis triggered by withdrawal of… CONTINUE READING

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