Regulation of Mutant p53 Protein Expression

@article{Vijayakumaran2015RegulationOM,
  title={Regulation of Mutant p53 Protein Expression},
  author={Reshma Vijayakumaran and Kah Hin Tan and Panimaya Jeffreena Miranda and Sue Haupt and Ygal Haupt},
  journal={Frontiers in oncology},
  year={2015},
  volume={5},
  pages={284}
}
For several decades, p53 has been detected in cancer biopsies by virtue of its high protein expression level which is considered indicative of mutation. Surprisingly, however, mouse genetic studies revealed that mutant p53 is inherently labile, similar to its wild type (wt) counterpart. Consistently, in response to stress conditions, both wt and mutant p53… CONTINUE READING