Regulation of Mitoflash Biogenesis and Signaling by Mitochondrial Dynamics

@inproceedings{Li2016RegulationOM,
  title={Regulation of Mitoflash Biogenesis and Signaling by Mitochondrial Dynamics},
  author={Wenwen Li and Tao Sun and Beibei Liu and Di Wu and Wenfeng Qi and Xianhua Wang and Qi Si Ma and Heping Cheng},
  booktitle={Scientific reports},
  year={2016}
}
Mitochondria are highly dynamic organelles undergoing constant network reorganization and exhibiting stochastic signaling events in the form of mitochondrial flashes (mitoflashes). Here we investigate whether and how mitochondrial network dynamics regulate mitoflash biogenesis and signaling. We found that mitoflash frequency was largely invariant when network fragmentized or redistributed in the absence of mitofusin (Mfn) 1, Mfn2, or Kif5b. However, Opa1 deficiency decreased spontaneous… CONTINUE READING