Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes

@inproceedings{Morino2012RegulationOM,
  title={Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes},
  author={Katsutaro Morino and Kitt Falk Petersen and Saki Sono and Cheol Soo Choi and Varman T Samuel and Aiping Lin and Amy M Gallo and Hongyu Zhao and Atsunori Kashiwagi and Ira J Goldberg and Hong Wang and Robert H Eckel and Hiroshi Maegawa and Gerald I Shulman},
  booktitle={Diabetes},
  year={2012}
}
Recent studies reveal a strong relationship between reduced mitochondrial content and insulin resistance in human skeletal muscle, although the underlying factors responsible for this association remain unknown. To address this question, we analyzed muscle biopsy samples from young, lean, insulin resistant (IR) offspring of parents with type 2 diabetes and control subjects by microarray analyses and found significant differences in expression of ~512 probe pairs. We then screened these genes… CONTINUE READING