Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1

  title={Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1},
  author={Gayatri Pal and Maria T.Z. Paraz and Douglas R. Kellogg},
  journal={The Journal of Cell Biology},
  pages={931 - 945}
The Cdc25 phosphatase promotes entry into mitosis by removing cyclin-dependent kinase 1 (Cdk1) inhibitory phosphorylation. Previous work suggested that Cdc25 is activated by Cdk1 in a positive feedback loop promoting entry into mitosis; however, it has remained unclear how the feedback loop is initiated. To learn more about the mechanisms that regulate entry into mitosis, we have characterized the function and regulation of Mih1, the budding yeast homologue of Cdc25. We found that Mih1 is… CONTINUE READING
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