Regulation of Membrane Flexibility in Human Erythrocytes.

@article{Kury1975RegulationOM,
  title={Regulation of Membrane Flexibility in Human Erythrocytes.},
  author={P G Kury and MOYRA MCCONNELL},
  journal={Biochemistry},
  year={1975},
  volume={14 13},
  pages={2798-803}
}
We have used spin-labels to detect prostaglandin E induced changes in erythrocyte membranes. The observed changes in spin-label resonance spectra can be mimicked in erythrocyte ghosts by loading them with cAMP or cGMP. These changes can also be observed by adding either of these cyclic nucleotides to intact cells. This entry of cyclic nucleotides into intact cells is blocked by an inhibitor of the anion channel. We suggest that the observed changes in paramagnetic resonance spectra are due to… CONTINUE READING