Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

@inproceedings{Devereaux2013RegulationOM,
  title={Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis},
  author={Kelly Devereaux and Claudia Dall’Armi and Abel R. Alc{\'a}zar-Rom{\'a}n and Yuta Ogasawara and Xiang Zhou and Fan Wang and Akitsugu Yamamoto and Pietro De Camilli and Gabriella Di Paolo},
  booktitle={PloS one},
  year={2013}
}
Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) biogenesis. Although Vps34 is the sole source of PI3P in budding yeast, mammalian cells can produce PI3P through alternate pathways, including direct synthesis by the class II PI3Ks; however, the physiological relevance of these alternate pathways in the context of autophagy is unknown. Here we generated Vps34 knockout mouse… CONTINUE READING

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