Regulation of Macrophage Polarization and Wound Healing.

  title={Regulation of Macrophage Polarization and Wound Healing.},
  author={Christopher James Ferrante and Samuel Joseph Leibovich},
  journal={Advances in wound care},
  volume={1 1},
BACKGROUND Macrophages (Mφs) participate in wound healing by coordinating inflammatory and angiogenic processes. Mφs respond to environmental cues by adopting either "classically" activated (M1) proinflammatory or "alternatively" activated (M2a, M2b, M2c, M2d) wound healing phenotypes. THE PROBLEM Mφ polarization is essential for wound healing and aberrations in this process are linked to several pathologies. It is important to elucidate molecular mechanisms underlying Mφ polarization… CONTINUE READING


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