Regulation of MMPs and TIMPs by IL-1beta during corneal ulceration and infection.

@article{Xue2003RegulationOM,
  title={Regulation of MMPs and TIMPs by IL-1beta during corneal ulceration and infection.},
  author={Mei Lang Xue and Denis Wakefield and Mark Willcox and Andrew R. Lloyd and Nick Di Girolamo and Nerida Cole and Archana N. Thakur},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 5},
  pages={2020-5}
}
PURPOSE This study was conducted to investigate the role of IL-1beta in the regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in a mouse model of experimental keratitis and corneal injury. METHODS Mice were injected subconjunctivally with 10 micro g of anti-mouse IL-1beta antibody 2 hours before challenge with Pseudomonas aeruginosa (strain 6294). Control animals received an equal volume and concentration of isotype control antibody at the same… CONTINUE READING

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