Regulation of MHC class II gene expression by the class II transactivator

Abstract

MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern. This complex gene-expression profile is… (More)
DOI: 10.1038/nri1708

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