Regulation of MEIS1 by Distal Enhancer Elements in Acute Leukemia

  title={Regulation of MEIS1 by Distal Enhancer Elements in Acute Leukemia},
  author={Qian-fei Wang and Yajun Li and Jing-fang Dong and Bo Li and Joseph J. Kaberlein and Lin Zhang and F{\'a}bio Eiji Arimura and Roger T. Luo and Jun Ni and Fuhong He and Jun Wu and Ryan James Mattison and Jing Zhou and Chong-zhi Wang and Shyam Prabhakar and Marcelo A. Nobrega and Michael Thirman},
Aberrant activation of the three-amino-acid-loop extension homeobox gene MEIS1 shortens the latency and accelerates the onset and progression of acute leukemia, yet the molecular mechanism underlying persistent activation of the MEIS1 gene in leukemia remains poorly understood. Here we used a combined comparative genomics analysis and an in vivo transgenic zebrafish assay to identify six regulatory DNA elements that are able to direct green fluorescent protein expression in a spatiotemporal… CONTINUE READING
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