Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.

@article{Sunohara2001RegulationOM,
  title={Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.},
  author={Janet R Sunohara and Neale D Ridgway and Harold W. Cook and David M. Byers},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 3},
  pages={
          664-72
        }
}
Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) have been implicated in membrane-cytoskeletal events underlying cell adhesion, migration, secretion, and phagocytosis. In BV-2 microglial cells, lipopolysaccharide (LPS) elicited a dose-dependent increase in mRNA of both MRP (sixfold) and MARCKS (threefold) with corresponding increases in [3H]myristoylated and immunoreactive protein levels. LPS also produced significant increases in protein kinase C (PKC… CONTINUE READING

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