Regulation of LPS-induced molecules by progesterone in cultured human cervical fibroblasts under different treatment conditions

@inproceedings{Kuwabara2015RegulationOL,
  title={Regulation of LPS-induced molecules by progesterone in cultured human cervical fibroblasts under different treatment conditions},
  author={Yoshimitsu Kuwabara and Akira Katayama and Sachiko Kurihara and Saori Yoshikawa and Mirei Yonezawa and Nozomi Ouchi and Ryuhei Kurshina and Ryuichi Sawa and Toshiyuki Takeshita},
  year={2015}
}
Objective:Wepreviously reported that progesterone (P4) treatment did not suppress LPS-induced upregulation of IL6 and IL8 in cultured human cervical fibroblasts. Here, we analyzed the expression of molecules associated with the pathophysiology of preterm labor under different levels of inflammatory stimulation (LPS stimulation) and/or the timing of progesterone treatment. Method of study: Human uterine cervical fibroblast cultures were established and incubated for 12h with 2.0 g/mL LPS… CONTINUE READING

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