Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms.

  title={Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms.},
  author={Sangita P Patel and Rajarshi Parai and Rita Parai and Donald L. Campbell},
  journal={The Journal of physiology},
  volume={557 Pt 1},
We conducted a kinetic analysis of the voltage dependence of macroscopic inactivation (tau(fast), tau(slow)), closed-state inactivation (tau(closed,inact)), recovery (tau(rec)), activation (tau(act)), and deactivation (tau(deact)) of Kv4.3 channels expressed alone in Xenopus oocytes and in the presence of the calcium-binding ancillary subunits KChIP2b and KChIP2d. We demonstrate that for all expression conditions, tau(rec), tau(closed,inact) and tau(fast) are components of closed-state… CONTINUE READING

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