Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.

@article{Vacher2007RegulationOK,
  title={Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.},
  author={H{\'e}l{\`e}ne Vacher and Durga P Mohapatra and Hiroaki Misonou and James S Trimmer},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 3},
  pages={906-14}
}
Modulation of voltage-gated potassium (Kv) channel surface expression can profoundly affect neuronal excitability. Some, but not all, mammalian Shaker or Kv1 alpha subunits contain a dominant endoplasmic reticulum (ER) retention signal in their pore region, preventing surface expression of Kv1.1 homotetrameric channels and of heteromeric Kv1 channels containing more than one Kv1.1 subunit. The critical amino acid residues within this ER pore-region retention signal are also critical for high… CONTINUE READING

From This Paper

Topics from this paper.
14 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…