Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification.

@article{Hang2014RegulationOK,
  title={Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification.},
  author={Lisa E. Hang and Christopher R. Lopez and Xianpeng Liu and Jaime M. Williams and Inn Chung and Lei Wei and Alison A Bertuch and Xiaolan Zhao},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 15},
  pages={10308-17}
}
The Ku70-Ku80 ring complex encloses DNA ends to facilitate telomere maintenance and DNA break repair. Many studies focus on the ring-forming regions of subunits Ku70 and Ku80. Less is known about the Ku70 C-terminal tail, which lies outside the ring. Our results suggest that this region is responsible for dynamic sumoylation of Yku70 upon DNA association in budding yeast. Mutating a cluster of five lysines in this region largely eliminates Yku70 sumoylation. Chromatin immunoprecipitation… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Sumoylation Regulates Functions of Ku 10316 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • H. R. Silver, J. A. Nissley, S. H. Reed, Y. M. Hou, E. S. Johnson
  • APRIL 11,
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…