Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells.

@article{Chen2004RegulationOK,
  title={Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells.},
  author={Ceshi Chen and Yingfa Zhou and Zhongmei Zhou and Xiaodong Sun and Kristen B. Otto and Rosalie M. Uht and Jin-Tang Dong},
  journal={Gene},
  year={2004},
  volume={330},
  pages={133-42}
}
Human Kruppel-like factor 5 (hKLF5) is a transcription factor with a potential tumor suppressor function in prostate and breast cancers. In the majority of cancer samples examined, a significant loss of expression for KLF5 has been detected. Whereas hemizygous deletion appears to be responsible for KLF5's reduced expression in about half of the cases, the mechanism for reduction is unknown in the remaining half; gene promoter methylation does not appear to be involved. In this report, we… CONTINUE READING

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