Regulation of KCacurrent by store-operated Ca2+influx depends on internal Ca2+release in HSG cells.

@article{Liu1998RegulationOK,
  title={Regulation of KCacurrent by store-operated Ca2+influx depends on internal Ca2+release in HSG cells.},
  author={Xibao Liu and Eduardo Rojas and Indu S Ambudkar},
  journal={The American journal of physiology},
  year={1998},
  volume={275 2 Pt 1},
  pages={C571-80}
}
This study examines the Ca2+ influx-dependent regulation of the Ca2+-activated K+ channel (KCa) in human submandibular gland (HSG) cells. Carbachol (CCh) induced sustained increases in the KCa current and cytosolic Ca2+ concentration ([Ca2+]i), which were prevented by loading cells with 1,2-bis(2-aminophenoxy)ethane- N, N, N', N'-tetraacetic acid (BAPTA). Removal of extracellular Ca2+ and addition of La3+ or Gd3+, but not Zn2+, inhibited the increases in KCa current and [Ca2+]i. Ca2+ influx… CONTINUE READING