Regulation of K Flow by a Ring of Negative Charges in the Outer Pore of BK Ca Channels . Part II : Neutralization of Aspartate 292 Reduces Long Channel Openings and Gating Current Slow Component

Neutralization of the aspartate near the selectivity filter in the GYG D pore sequence (D292N) of the voltageand Ca 2 -activated K channel (MaxiK, BKCa) does not prevent conduction like the corresponding mutation in Shaker channel, but profoundly affects major biophysical properties of the channel (Haug, T., D. Sigg, S. Ciani, L. Toro, E. Stefani, and R… CONTINUE READING