Regulation of JNK signaling by GSTp.

@article{Adler1999RegulationOJ,
  title={Regulation of JNK signaling by GSTp.},
  author={Victor Adler and Zhimin Yin and Serge Yu. Fuchs and Miriam Benezra and Luis Rosario and Kenneth D. Tew and Matthew R. Pincus and Mohinder Sardana and Colin J. Henderson and C. R. Wolf and Roger J Davis and Ze'ev A Ronai},
  journal={The EMBO journal},
  year={1999},
  volume={18 5},
  pages={
          1321-34
        }
}
Studies of low basal Jun N-terminal kinase (JNK) activity in non-stressed cells led us to identify a JNK inhibitor that was purified and identified as glutathione S-transferase Pi (GSTp) and was characterized as a JNK-associated protein. UV irradiation or H2O2 treatment caused GSTp oligomerization and dissociation of the GSTp-JNK complex, indicating that it is the monomeric form of GSTp that elicits JNK inhibition. Addition of purified GSTp to the Jun-JNK complex caused a dose-dependent… CONTINUE READING

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