Regulation of J6 gene expression by transcription factor GATA-4.

  title={Regulation of J6 gene expression by transcription factor GATA-4.},
  author={Malgorzata Bielinska and David B. Wilson},
  journal={The Biochemical journal},
  volume={307 ( Pt 1)},
Retinoic acid-induced differentiation of mouse F9 embryonal carcinoma cells into primitive endoderm is accompanied by increased transcription of the gene for J6, a heat shock protein implicated in collagen biosynthesis. In this paper we present evidence that transcription factor GATA-4, a retinoic acid-inducible GATA-binding protein, is involved in the regulation of J6 gene expression in F9 cells. Northern-blot analysis indicates that transcripts encoding GATA-4 and J6 increase in parallel… CONTINUE READING