Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes*

@article{Ogata1998RegulationOI,
  title={Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes*},
  author={Haruki Ogata and D. Ford and N. Kouttab and T. King and N. Vita and A. Minty and J. Stoeckler and Deborah Morgan and C. Girasole and J. Morgan and A. Maizel},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={9864 - 9871}
}
Human B cells stimulated through both their immunoglobulin and CD40 receptors up-regulate 745 ± 51 interleukin (IL)-13 ligand binding sites with an affinity of 0.91 ± 0.08 nm within 24 h. IL-13 binds primarily to the IL-13Rα1 with subsequent sequestration of the IL-4Rα into the complex. IL-13Rα1 may also be found in those receptors capable of binding IL-4. γ chain (γc) participates in receptors capable of binding IL-4 but is not found in association with bound IL-13. Dimeric receptors composed… Expand
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