Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes*

@article{Ogata1998RegulationOI,
  title={Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes*},
  author={Haruki Ogata and Dwayne Ford and Nicola Mitri Kouttab and Thomas C. King and Natalio Vita and Adrian J. Minty and Johanna D. Stoeckler and D M Morgan and Christopher R. Girasole and John W Morgan and Abby L. Maizel},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={9864 - 9871}
}
Human B cells stimulated through both their immunoglobulin and CD40 receptors up-regulate 745 ± 51 interleukin (IL)-13 ligand binding sites with an affinity of 0.91 ± 0.08 nm within 24 h. IL-13 binds primarily to the IL-13Rα1 with subsequent sequestration of the IL-4Rα into the complex. IL-13Rα1 may also be found in those receptors capable of binding IL-4. γ chain (γc) participates in receptors capable of binding IL-4 but is not found in association with bound IL-13. Dimeric receptors composed… 

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