Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins

  title={Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins},
  author={Rachel D. Starks and Andreas M Beyer and Deng Fu Guo and Lauren Boland and Qihong Zhang and Val C. Sheffield and Kamal Rahmouni},
  booktitle={PLoS genetics},
Insulin and its receptor are critical for the regulation of metabolic functions, but the mechanisms underlying insulin receptor (IR) trafficking to the plasma membrane are not well understood. Here, we show that Bardet Biedl Syndrome (BBS) proteins are necessary for IR localization to the cell surface. We demonstrate that the IR interacts physically with BBS proteins, and reducing the expression of BBS proteins perturbs IR expression in the cell surface. We show the consequence of disrupting… CONTINUE READING
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