Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure

@inproceedings{Soski2011RegulationOI,
  title={Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure},
  author={Sanja S Soski{\'c} and Branislava D Dobutovi{\'c} and Emina M Sudar and Milan Obradovic and Dragana M Nikoli{\'c} and Jelena D Djordjevic and Djordje J. Radak and Dimitri P. Mikhailidis and Esma R Isenovic},
  booktitle={The open cardiovascular medicine journal},
  year={2011}
}
Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. NO is a reactive oxygen species as well as a reactive nitrogen species. It is a free radical which mediates several biological effects. It is clear that the generation and actions of NO under physiological and pathophysiological conditions are regulated and extend to almost every cell type and function within the circulation. In mammals 3 distinct isoforms of NOS have been identified: neuronal NOS (nNOS… CONTINUE READING