Regulation of IgE synthesis: from the membrane to the genes

  title={Regulation of IgE synthesis: from the membrane to the genes},
  author={Donata Vercelli and Raif S Geha},
  journal={Springer Seminars in Immunopathology},
The data discussed above clearly indicate that the second signal(s) required for IgE production can be delivered to B cells through different pathways. At the present time, no unifying explanatory mechanism can reconcile all different observations. Not much is known about signalling via MHC class II molecules and CD40; the role played by hydrocortisone is not clear, and other molecules — in addition to CD40 and its ligand — might be involved in non-cognate T-B cell interactions. Signalling via… CONTINUE READING