Regulation of IgE production requires oligomerization of CD23.

@article{Kilmon2001RegulationOI,
  title={Regulation of IgE production requires oligomerization of CD23.},
  author={Michelle A. Kilmon and Rodolfo Ghirlando and Marie Paule Strub and Rebecca L. Beavil and Hannah J Gould and Daniel H Conrad},
  journal={Journal of immunology},
  year={2001},
  volume={167 6},
  pages={
          3139-45
        }
}
Here we describe the production of a rabbit polyclonal Ab (RAS1) raised against the stalk of murine CD23. RAS1 inhibits release of CD23 from the surface of both M12 and B cells resulting in an increase of CD23 on the cell surface. Despite this increase, these cells are unable to bind IgE as determined by FACS. CD23 has previously been shown to bind IgE with both a high (4-10 x 10(7) M(-1)) and low (4-10 x 10(6) M(-1)) affinity. Closer examination by direct binding of (125)I-IgE revealed that… CONTINUE READING
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