Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA.

@article{Kunimoto1988RegulationOI,
  title={Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA.},
  author={Dennis Y Kunimoto and Gregory R. Harriman and Warren Strober},
  journal={Journal of immunology},
  year={1988},
  volume={141 3},
  pages={713-20}
}
In these studies we utilized the Ag (SRBC)-reactive B cell line CH12LX to study isotype switching. CH12LX cells are a stable population of B cells mainly bearing membrane IgM (mIgM) (98 to 99%) with a small population of B cells bearing membrane IgA (mIgA) (1 to 2%). LPS induced a 5- to 10-fold increase in the secretion of both Ig, whereas a lymphokine-rich supernatant of D10 T cells induced a greater increase in the secretion of IgA than IgM. Analysis of the latter effect with recombinant… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Regulation of IgA B-cell development in the mucosal immune system

Journal of Clinical Immunology • 1990
View 2 Excerpts

Similar Papers

Loading similar papers…