Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer.

@article{Gautschi2008RegulationOI,
  title={Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer.},
  author={Oliver Gautschi and Clifford G Tepper and Phillip R. Purnell and Yoshihiro Izumiya and Christopher P Evans and Tim P. Green and Pierre Yves Desprez and Primo N. Lara and David R. Gandara and Philip C. Mack and Hsing-Jien Kung},
  journal={Cancer research},
  year={2008},
  volume={68 7},
  pages={
          2250-8
        }
}
Deregulated activation of the Src tyrosine kinase and heightened Id1 expression are independent mediators of aggressive tumor biology. The present report implicates Src signaling as a critical regulator of Id1 gene expression. Microarray analyses showed that Id family genes were among the most highly down-regulated by incubation of A549 lung carcinoma cells with the small-molecule Src inhibitor AZD0530. Id1 transcript and protein levels were potently reduced in a dose-dependent manner… CONTINUE READING

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