Regulation of ITAM signaling by specific sequences in Ig-beta B cell antigen receptor subunit.

@article{Cassard1996RegulationOI,
  title={Regulation of ITAM signaling by specific sequences in Ig-beta B cell antigen receptor subunit.},
  author={Sylvanie Cassard and Daniel Choquet and Wolf Herman Fridman and Christian Bonnerot},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 39},
  pages={23786-91}
}
B cell antigen receptors (BCR) are composed of an antigen binding subunit, the membrane Ig, and Ig-alpha/Ig-beta heterodimers, that contain a transducing motif named ITAM for "immuno-receptor tyrosine-based activation motif." Ig-alpha and Ig-beta ITAMs only differ by four amino acids located before the second conserved tyrosine (DCSM in Ig-alpha and QTAT in Ig-beta), which determine the in vitro association of Ig-alpha with the src kinase fyn. We have previously shown that Ig-alpha and Ig-beta… CONTINUE READING

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