Regulation of IMP dehydrogenase gene expression by its end products, guanine nucleotides.

@article{Glesne1991RegulationOI,
  title={Regulation of IMP dehydrogenase gene expression by its end products, guanine nucleotides.},
  author={David A Glesne and Frank R. Collart and Eliezer Huberman},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 11},
  pages={5417-25}
}
To study the regulation of IMP dehydrogenase (IMPDH), the rate-limiting enzyme of guanine nucleotide biosynthesis, we examined the effects of nucleosides, nucleotides, nucleotide analogs, or the IMPDH inhibitor mycophenolic acid (MPA) on the steady-state levels of IMPDH mRNA. The results indicated that IMPDH gene expression is regulated inversely by the intracellular level of guanine ribonucleotides. We have shown that treatment with guanosine increased the level of cellular guanine… CONTINUE READING

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