Regulation of IL-4 expression by activation of individual alleles.

@article{Rivire1998RegulationOI,
  title={Regulation of IL-4 expression by activation of individual alleles.},
  author={Isabelle Rivi{\'e}re and Mary Jean Sunshine and Dan R. Littman},
  journal={Immunity},
  year={1998},
  volume={9 2},
  pages={217-28}
}
To study the in vivo role of IL-4-expressing cells, we developed a strategy to tag these cells, by generating mice in which one IL-4 allele was replaced with a cDNA encoding the human CD2 (huCD2) cell-surface molecule. Expression of the huCD2 reporter was, like IL-4, restricted to the appropriately polarized T helper 2 cells. However, most of the cells expressed only the IL-4 or the targeted allele. Analysis of the frequency of monoallelic versus biallelic expression suggests that the… CONTINUE READING

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