Regulation of IL-1 and TNF Receptor Expression and Function by Endogenous Macrophage Migration Inhibitory Factor1

@article{Toh2006RegulationOI,
  title={Regulation of IL-1 and TNF Receptor Expression and Function by Endogenous Macrophage Migration Inhibitory Factor1},
  author={M. Toh and D. Aeberli and D. Lacey and Y. Yang and Leilani L. Santos and M. Clarkson and L. Sharma and C. Clyne and E. Morand},
  journal={The Journal of Immunology},
  year={2006},
  volume={177},
  pages={4818 - 4825}
}
Macrophage migration inhibitory factor (MIF) has a key role in regulation of innate and adaptive immunity and is implicated in sepsis, tumorigenesis, and autoimmune disease. MIF deficiency or immunoneutralization leads to protection against fatal endotoxic, exotoxic, and infective shock, and anti-inflammatory effects in other experimental models of inflammatory disease. We report a novel regulatory role of MIF in type 1 IL-1R and p55 TNFR expression and function. Compared with wild-type cells… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response
TLDR
Macrophage migration inhibitory factor (MIF), a product of activated macrophages, sustains macrophage survival and function by suppressing activation-induced, p53-dependent apoptosis and suggests new approaches for the modulation of innate immune responses. Expand
Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids.
TLDR
These data represent the first demonstration of the cytokine MIF in human autoimmune disease and suggest MIF as a potential therapeutic target in RA. Expand
Involvement of Macrophage Migration Inhibitory Factor (MIF) in the Mechanism of Tumor Cell Growth
TLDR
The current results suggest the possibility that MIF induces tumor cell growth in concert with other growth factors, which encouraged us to investigate a novel approach for tumor therapy using an anti-MIF antibody and an MIF anti-sense plasmid transfection technique. Expand
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
TLDR
It is concluded that MIF may act broadly to negatively regulate Jab1-controlled pathways and that the MIF–Jab1 interaction may provide a molecular basis for key activities of MIF. Expand
Targeted Disruption of Migration Inhibitory Factor Gene Reveals Its Critical Role in Sepsis
TLDR
The findings of enhanced resistance to P. aeruginosa and resistance to endotoxin-induced lethal shock suggest that the counteraction or neutralization of MIF may serve as an adjunct therapy in sepsis. Expand
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria.
TLDR
Gram-positive exotoxins are extremely potent inducers of MIF secretion and establish a critical role for MIF and the macrophage in the pathogenesis of the TSSs and in the innate immune response. Expand
MIF regulates innate immune responses through modulation of Toll-like receptor 4
TLDR
It is reported that MIF is an essential regulator of macrophage responses to endotoxin (lipopolysaccharide) and Gram-negative bacteria and provides a molecular basis for the resistance of MIF-deficient mice to endotoxic shock. Expand
Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor.
TLDR
MIF activates RA FLS COX-2 and IL-6 expression via p 38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinases-independent pathways. Expand
MIF as a glucocorticoid-induced modulator of cytokine production
TLDR
The unexpected finding that low con-centrations of glucocorticoids induce rather than inhibit MIF production from macrophages is reported, identifying a unique counter-regulatory system that functions to control inflammatory and immune responses. Expand
An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.
  • M. Bacher, C. Metz, +6 authors R. Bucala
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
It is reported that MIF plays an important regulatory role in the activation of T cells induced by mitogenic or antigenic stimuli and assigned a previously unsuspected but critical role for MIF in antigen-specific immune responses. Expand
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