Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin.

@article{Wang2011RegulationOI,
  title={Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin.},
  author={Feng Wang and Takeshi Ijuin and Toshiki Itoh and Tadaomi Takenawa},
  journal={Journal of biochemistry},
  year={2011},
  volume={150 1},
  pages={
          83-93
        }
}
Pharbin, a 5-phosphatase that induces arborization, is one of the phosphoinositide 5-phosphatases that is highly mutated in patients with Joubert syndrome. Pharbin can hydrolyse PI(4,5)P(2) and PI(3,4,5)P(3) and has the same substrate specificity as SHIP2 and SKIP, which negatively regulate PI3K signalling. Here, we investigated the role of pharbin in IGF-1/PI3K signalling. Ectopic expression of pharbin markedly suppressed the IGF-1-induced activation of Akt without affecting p42/44 MAP kinase… CONTINUE READING

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