Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase.

@article{Zadeh2000RegulationOI,
  title={Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase.},
  author={Majid Sadeghi Zadeh and J. P. Kolb and Daniela Geromin and R D'Anna and A Boulmerka and Anthony Marconi and Bernard Dugas and C{\'e}cile Marsac and Patrizia d'Alessio},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={67 3},
  pages={327-34}
}
Expression of the inducible isoform of nitric oxide synthase (iNOS) is stimulated by cytokines in human epithelial cells. This work indicates that incubation of human umbilical cord endothelial cells with combinations of interleukin-1beta, tumor necrosis factor alpha, and interferon-gamma stimulated the synthesis of iNOS mRNA, as detected by reverse transcriptase-polymerase chain reaction. It is important to note that 50, 100, and 200 microM hydrogen peroxide was able to stimulate iNOS directly… CONTINUE READING

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The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for g-glutamylcysteine synthetase and g-glutamyl transpeptidase

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