Regulation of Human Osteoclast Differentiation by Thioredoxin Binding Protein‐2 and Redox‐Sensitive Signaling

@article{Aitken2004RegulationOH,
  title={Regulation of Human Osteoclast Differentiation by Thioredoxin Binding Protein‐2 and Redox‐Sensitive Signaling},
  author={C. J. Aitken and J. Hodge and Y. Nishinaka and T. Vaughan and J. Yodoi and Chris J Day and N. Morrison and G. Nicholson},
  journal={Journal of Bone and Mineral Research},
  year={2004},
  volume={19}
}
Differential expression of TBP‐2 and Trx‐1 occurs during osteoclastogenesis. Adenoviral overexpression of TBP‐2 in osteoclast precursors inhibits Trx‐1 expression, osteoclast formation, and AP‐1 binding activity. TBP‐2 and Trx‐1 are key regulators of osteoclastogenesis. 
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