Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.

@article{Ryoo1999RegulationOH,
  title={Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.},
  author={Hyung Don Ryoo and Thomas Marty and Fernando Casares and Markus Affolter and Richard S. Mann},
  journal={Development},
  year={1999},
  volume={126 22},
  pages={
          5137-48
        }
}
To regulate their target genes, the Hox proteins of Drosophila often bind to DNA as heterodimers with the homeodomain protein Extradenticle (EXD). For EXD to bind DNA, it must be in the nucleus, and its nuclear localization requires a third homeodomain protein, Homothorax (HTH). Here we show that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization of EXD in vivo. However, mutating a key DNA binding residue in the HTH… Expand
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