Regulation of Homer and group I metabotropic glutamate receptors by nicotine.

  title={Regulation of Homer and group I metabotropic glutamate receptors by nicotine.},
  author={Justin K. Kane and Y Hwang and Ozlen Konu and Sandra E Loughlin and Frances M. Leslie and Ming Da Li},
  journal={The European journal of neuroscience},
  volume={21 5},
The present study focuses on the nicotine-induced modulation of mRNA and protein expression of a number of genes involved in glutamatergic synaptic transmission in rat brain over different time periods of exposure. A subchronic (3 days) but not the chronic (7 or 14 days) administration of nicotine resulted in the up-regulation of Homer2a/b mRNA in the amygdala while in the ventral tegmental area (VTA) no change in expression of either Homer2a/b or Homer1b/c was observed. Although the increase… CONTINUE READING
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