Regulation of Hippocampal cGMP Levels as a Candidate to Treat Cognitive Deficits in Huntington’s Disease

@inproceedings{Saavedra2013RegulationOH,
  title={Regulation of Hippocampal cGMP Levels as a Candidate to Treat Cognitive Deficits in Huntington’s Disease},
  author={Ana Saavedra and Albert Giralt and Helena Arum{\'i} and Jordi Alberch and Esther P{\'e}rez-Navarro},
  booktitle={PloS one},
  year={2013}
}
Huntington's disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide synthase/3',5'-cyclic guanosine monophosphate (nNOS/cGMP) pathway is implicated in synaptic plasticity, and in learning and memory processes. Here, we examined the nNOS/cGMP pathway in the hippocampus of… CONTINUE READING