Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory

@article{Sousa2011RegulationOH,
  title={Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory},
  author={Vasco Cabral Sousa and Nat{\'a}lia Assaife-Lopes and Joaquim Alexandre Ribeiro and Judith A. Pratt and R. Brett and Ana M. Sebasti{\~a}o},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={472-487}
}
The cannabinoid CB1 receptor-mediated modulation of γ-aminobutyric acid (GABA) release from inhibitory interneurons is important for the integrity of hippocampal-dependent spatial memory. Although adenosine A1 receptors have a central role in fine-tuning excitatory transmission in the hippocampus, A1 receptors localized in GABAergic cells do not directly… CONTINUE READING