Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

@article{Volpe2002RegulationOH,
  title={Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi},
  author={Thomas A. Volpe and C. Kidner and I. Hall and G. Teng and S. Grewal and R. Martienssen},
  journal={Science},
  year={2002},
  volume={297},
  pages={1833 - 1837}
}
  • Thomas A. Volpe, C. Kidner, +3 authors R. Martienssen
  • Published 2002
  • Medicine, Biology
  • Science
  • Eukaryotic heterochromatin is characterized by a high density of repeats and transposons, as well as by modified histones, and influences both gene expression and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, we deleted the argonaute, dicer, and RNA-dependent RNA polymerase gene homologs, which encode part of the machinery responsible for RNA interference (RNAi). Deletion results in the aberrant accumulation of complementary transcripts from centromeric heterochromatic… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 1,498 CITATIONS, ESTIMATED 64% COVERAGE

    RNAi-directed assembly of heterochromatin in fission yeast.

    VIEW 8 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    RNAi-dependent formation of heterochromatin and its diverse functions.

    RNA interference and heterochromatin assembly.

    VIEW 8 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2002
    2020

    CITATION STATISTICS

    • 95 Highly Influenced Citations

    • Averaged 49 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 34 REFERENCES

    D

    VIEW 1 EXCERPT

    Allshire for sharing antibodies and unpublished data Heard for helpful discussions Krimper for technical help

    • the Watson School Undergraduate Research Program. This work was supported by an NCI postdoctoral training fellowship to T.V., grants from the Ellison Medical Foundation and NIH (GM59772) to S.G., and a grant from the National Science Foundation

    Cell

    • Cell
    • 1993

    Cold Spring Harb. Symp. Quant. Biol

    • Cold Spring Harb. Symp. Quant. Biol
    • 1993

    Curr Biol

    • Curr Biol
    • 2001

    Curr. Opin. Genet. Dev

    • Curr. Opin. Genet. Dev
    • 1992

    Curr. Opin. Genet. Dev

    • Curr. Opin. Genet. Dev
    • 2002

    Curr. Opin. Genet. Dev

    • Curr. Opin. Genet. Dev
    • 1998

    Curr. Opin. Genet. Dev

    • Curr. Opin. Genet. Dev
    • 2001