Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

@article{Volpe2002RegulationOH,
  title={Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi},
  author={Thomas A. Volpe and Catherine A Kidner and Ira M. Hall and Grace Teng and Shiv I. S. Grewal and Robert A. Martienssen},
  journal={Science},
  year={2002},
  volume={297},
  pages={1833 - 1837}
}
Eukaryotic heterochromatin is characterized by a high density of repeats and transposons, as well as by modified histones, and influences both gene expression and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, we deleted the argonaute, dicer, and RNA-dependent RNA polymerase gene homologs, which encode part of the machinery responsible for RNA interference (RNAi). Deletion results in the aberrant accumulation of complementary transcripts from centromeric heterochromatic… Expand
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