Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

@inproceedings{Lei2009RegulationOH,
  title={Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration},
  author={Zhang Lei and Bo Li and Zhuoshun Yang and Haoshu Fang and Gui-mei Zhang and Zuo-hua Feng and Bo Huang},
  booktitle={PloS one},
  year={2009}
}
The regulation of HIF-1alpha is considered to be realized by pVHL-mediated ubiquitin-26S proteasome pathway at a post-transcriptional level. The discovery of a class of small noncoding RNAs, called microRNAs, implies alternative mechanism of regulation of HIF-1alpha. Here, we show that miR-20b plays an important role in fine-tuning the adaptation of tumor cells to oxygen concentration. The inhibition of miR-20b increased the protein levels of HIF-1alpha and VEGF in normoxic tumor cells; the… CONTINUE READING
80 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 80 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…