Regulation of Greatwall kinase during Xenopus oocyte maturation

  title={Regulation of Greatwall kinase during Xenopus oocyte maturation},
  author={Tomomi M. Yamamoto and Kristina A. Blake-Hodek and Byron C. Williams and Andrea L. Lewellyn and Michael L Goldberg and James L. Maller},
  booktitle={Molecular biology of the cell},
Greatwall kinase has been identified as a key element in M phase initiation and maintenance in Drosophila, Xenopus oocytes/eggs, and mammalian cells. In M phase, Greatwall phosphorylates endosulfine and related proteins that bind to and inhibit protein phosphatase 2A/B55, the principal phosphatase for Cdk-phosphorylated substrates. We show that Greatwall… CONTINUE READING