Regulation of Glucagon-like Peptide-1 Exocytosis from the Primary L-cell by the SNARE Protein Syntaxin-1a

Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal L-cell hormone that potentiates glucosedependent insulin secretion. To develop novel approaches for the treatment of type 2 diabetes, the capacity to enhance endogenous GLP-1 secretion from the L-cell is currently being explored. Although secretagogues that stimulate GLP-1 secretion have been identified, the… (More)

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