Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD15112

@inproceedings{Tilghman2016RegulationOG,
  title={Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD15112},
  author={Jessica I. Tilghman and Paula Schiapparelli and Bachuchu Lal and Mingyao Ying and Alfredo Quinones-Hinojosa and Shuli Xia and John Laterra},
  booktitle={Neoplasia},
  year={2016}
}
Glioblastoma (GBM) stem cells (GSCs) represent tumor-propagating cells with stem-like characteristics (stemness) that contribute disproportionately to GBM drug resistance and tumor recurrence. Understanding the mechanisms supporting GSC stemness is important for developing therapeutic strategies for targeting GSC-dependent oncogenic mechanisms. Using GBM-derived neurospheres, we identified the cell surface tetraspanin family member CD151 as a novel regulator of glioma cell stemness, GSC self… CONTINUE READING

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