Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids

@inproceedings{Hofbauer2014RegulationOG,
  title={Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids},
  author={Harald F Hofbauer and Florian H. Schopf and Hannes Schleifer and Oskar L. Knittelfelder and Bartholomaeus Pieber and Gerald N Rechberger and Heimo Wolinski and Mar{\'i}a L. Gaspar and C. Oliver Kappe and Johannes Stadlmann and Karl Mechtler and Alexandra Zenz and K. A. Lohner and Oksana Tehlivets and Susan A Henry and Sepp D. Kohlwein},
  booktitle={Developmental cell},
  year={2014}
}
Membrane phospholipids typically contain fatty acids (FAs) of 16 and 18 carbon atoms. This particular chain length is evolutionarily highly conserved and presumably provides maximum stability and dynamic properties to biological membranes in response to nutritional or environmental cues. Here, we show that the relative proportion of C16 versus C18 FAs is regulated by the activity of acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme of FA de novo synthesis. Acc1 activity is… CONTINUE READING
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