Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex

@article{Brandish2005RegulationOG,
  title={Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex},
  author={Philip E Brandish and Ming Wan Su and Daniel J. Holder and Paul Hodor and John Szumiloski and Robert R. Kleinhanz and Jaime E. Forbes and Mollie E. McWhorter and Sven J. Duenwald and Mark L. Parrish and Sang Hoon Na and Yuan Liu and Robert L. Phillips and John J. Renger and Sethu Sankaranarayanan and Adam J. Simon and Edward M. Scolnick},
  journal={Neuron},
  year={2005},
  volume={45},
  pages={861-872}
}
Lithium inhibits inositol monophosphatase at therapeutically effective concentrations, and it has been hypothesized that depletion of brain inositol levels is an important chemical alteration for lithium's therapeutic efficacy in bipolar disorder. We have employed adult rat cortical slices as a model to investigate the gene regulatory consequences of inositol depletion effected by lithium using cytidine diphosphoryl-diacylglycerol as a functionally relevant biochemical marker to define… CONTINUE READING