Regulation of GPR119 receptor activity with endocannabinoid-like lipids.

  title={Regulation of GPR119 receptor activity with endocannabinoid-like lipids.},
  author={Samreen K. Syed and Hai Hoang Bui and Lisa S. Beavers and Thomas Bradley Farb and James V. Ficorilli and Amy K Chesterfield and Ming-shang Kuo and Krister Bokvist and David G Barrett and Alexander M. Efanov},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={303 12},
The GPR119 receptor plays an important role in the secretion of incretin hormones in response to nutrient consumption. We have studied the ability of an array of naturally occurring endocannabinoid-like lipids to activate GPR119 and have identified several lipid receptor agonists. The most potent receptor agonists identified were three N-acylethanolamines: oleoylethanolamine (OEA), palmitoleoylethanolamine, and linoleylethanolamine (LEA), all of which displayed similar potency in activating… CONTINUE READING