• DOI:10.1152/AJPENDO.00512.2001
Corpus ID: 7891060

Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).

@article{Ojuka2002RegulationOG,
  title={Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).},
  author={E. Ojuka and T. E. Jones and L. Nolte and M. Chen and B. Wamhoff and M. Sturek and J. Holloszy},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 5},
  pages={
          E1008-13
        }
}

E. Ojuka, T. E. Jones, +4 authors J. Holloszy

Published 2002

Biology, Medicine

American journal of physiology. Endocrinology and metabolism

There is evidence suggesting that adaptive increases in GLUT4 and mitochondria in skeletal muscle occur in parallel. It has been reported that raising cytosolic Ca(2+) in myocytes induces increases in mitochondrial enzymes. In this study, we tested the hypothesis that an increase in cytosolic Ca(2+) induces an increase in GLUT4. We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor… CONTINUE READING

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