Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).

  title={Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).},
  author={E. Ojuka and T. E. Jones and L. Nolte and M. Chen and B. Wamhoff and M. Sturek and J. Holloszy},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={282 5},
  • E. Ojuka, T. E. Jones, +4 authors J. Holloszy
  • Published 2002
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
  • There is evidence suggesting that adaptive increases in GLUT4 and mitochondria in skeletal muscle occur in parallel. It has been reported that raising cytosolic Ca(2+) in myocytes induces increases in mitochondrial enzymes. In this study, we tested the hypothesis that an increase in cytosolic Ca(2+) induces an increase in GLUT4. We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor… CONTINUE READING
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