Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).
@article{Ojuka2002RegulationOG, title={Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).}, author={E. Ojuka and T. E. Jones and L. Nolte and M. Chen and B. Wamhoff and M. Sturek and J. Holloszy}, journal={American journal of physiology. Endocrinology and metabolism}, year={2002}, volume={282 5}, pages={ E1008-13 } }
There is evidence suggesting that adaptive increases in GLUT4 and mitochondria in skeletal muscle occur in parallel. It has been reported that raising cytosolic Ca(2+) in myocytes induces increases in mitochondrial enzymes. In this study, we tested the hypothesis that an increase in cytosolic Ca(2+) induces an increase in GLUT4. We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor… CONTINUE READING
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