Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2

@article{Lee2013RegulationOG,
  title={Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2},
  author={Yun‐Sil Lee and Se-Jin Lee},
  journal={Proceedings of the National Academy of Sciences},
  year={2013},
  volume={110},
  pages={E3713 - E3722}
}
  • Yun‐Sil Lee, Se-Jin Lee
  • Published 9 September 2013
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
Significance The TGF-β family encompasses a large number of secreted proteins that regulate embryonic development and adult tissue homeostasis. Growth and differentiation factor (GDF) -associated serum protein-1 (GASP-1) and GASP-2 are related proteins capable of binding and inhibiting two family members, myostatin and GDF-11. Here, we show that mice genetically engineered to lack GASP-1 and/or GASP-2 exhibit muscle and skeletal phenotypes consistent with overactivity of myostatin and/or GDF-11… 
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