Regulation of GATA-3 Expression during CD4 Lineage Differentiation

  title={Regulation of GATA-3 Expression during CD4 Lineage Differentiation},
  author={Idoia Gimferrer and Taishan Hu and Amie Simmons and Chi Wang and Abdallah Souabni and Meinrad Busslinger and Timothy P. Bender and Gabriela Hernández-Hoyos and Jos{\'e} Alberola-Ila},
  journal={The Journal of Immunology},
  pages={3892 - 3898}
GATA-3 is necessary for the development of MHC class II-restricted CD4 T cells, and its expression is increased during positive selection of these cells. TCR signals drive this upregulation, but the signaling pathways that control this process are not well understood. Using genetic and pharmacological approaches, we show that GATA-3 upregulation during thymocyte-positive selection is the result of additive inputs from the Ras/MAPK and calcineurin pathways. This upregulation requires the… 

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